Can phylogeographic approaches be used to study the within-host spread of HIV?
Le 25 Janvier 2019
11h30 - Campus Triolet Univ Montpellier: amphi 23.01 - Bât. 23
Roland REGOES
ETH, Zurich, Switzerland.
Roland Regoes has been investigating the population dynamical aspects of infections, focusing on how pathogens enter their hosts, spread between tissue compartments, and interact with the host’s immune system. In this talk, he will describe his group’s pursuits to apply phylogeographic methods to understand the within-host spread of HIV-1 – an application he termed phyloanatomy. Combining evidence from long-term HIV evolution experiments in vitro, and mathematical analysis of viral sequence data obtained from early HIV infection reveals strong parallel evolution that may impair phyloanatomic analysis.
Recent publications:
Bons & Regoes (2018) Virus dynamics and phyloanatomy: Merging population dynamic and phylogenetic approaches. Immunol Rev. 285(1):134-146.
Bons, Bertels & Regoes (2018) Estimating the mutational fitness effects distribution during early HIV infection. Virus Evol. 4(2):vey029.
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Contact:
Samuel Alizon - samuel.alizon@umontpellier.fr
Contact du Comité SEEM: seem@services.cnrs.fr. Contact du Labex CEMEB: cemeb-gestion@umontpellier.fr
