Effects of mutation and selection on gene expression

Patricia Wittkopp
Department of Ecology and Evolutionary Biology, University of Michigan, USA

wittkopp@umich.edu

Molecular mechanisms regulating gene expression play critical roles in development, physiology, and evolution. In this seminar, I will discuss how cis- and trans-acting factors controlling transcription vary within and between species and how new mutations affect these regulatory mechanisms. The impact of selection on this regulatory variation will also be discussed.

Related publications:

Duveau, F., A. Hodgins-Davis, B.P.H. Metzger, B. Yang, S. Tryban, E.A. Walker, P. Lybrook,  and P.J. Wittkopp. 2018 Fitness effects of altering gene expression noise in Saccharomyces cerevisiae, eLife.37272.001

Duveau, F., D.C. Yuan, B.P.H. Metzger, A. Hodgins-Davis, and P.J. Wittkopp. 2017 Effects of mutation and selection on plasticity of a promoter activity in Saccharomyces cerevisiae, PNAS 114:E11218-E11227

Metzger,B.P.H.1, D.C. Yuan1, J.D. Gruber, F. Duveau and P.J. Wittkopp*. (2015) Selection on noise constrains variation in a eukaryotic promoter. Nature 521:344-7